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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ATM/ATR-SKLB-197
SKLB-197

Chemical Structure : SKLB-197

CAS No.: 2713577-16-1

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SKLB-197 (SKLB197)

货号: PC-72744Not For Human Use, Lab Use Only.

SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.

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5 mg ￥2480 In stock
25 mg ￥5580 In stock
100 mg ￥14800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SKLB-197 is a potent and highly selective ATR kinase inhibitor with IC50 of 13 nM.
SKLB-197 displays very weak or no activity against other a panel of 402 protein kinases.
SKLB-197 exhibited potent antitumor activity against ATM-deficent tumors both in vitro and in vivo, with good pharmacokinetic properties.

物理化学性质&存储条件

分子量 424.508
分子式 C25H24N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

参考文献

1. Huachao Bin, et al. Eur J Med Chem. 2022 Mar 15;232:114187.

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