SKL2001 |CAS:909089-13-0 Probechem Biochemicals

Chemical Structure : SKL2001

CAS No.: 909089-13-0

加入收藏

SKL2001 (SKL 2001;SKL-2001)

货号: PC-35350Not For Human Use, Lab Use Only.

SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.

规格	价格	库存
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg	￥4280	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
SKL2001 strongly activates β-catenin responsive transcription, upregulates TOPflash reporter activity without effect on the activity of FOPFlash with mutated β-catenin/Tcf-binding elements, as well as either NF-κB or p53 reporter activity.
SKL2001 upregulates the expression of Axin2, inhibits N-terminal β-catenin phosphorylation without affecting GSK-3β activity.
SKL2001 suppresses preadipocyte differentiation, the alternative mesenchymal differentiation pathway.

物理化学性质&存储条件

分子量	286.291
分子式	C14H14N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide

参考文献

1. Gwak J, et al. Cell Res. 2012 Jan;22(1):237-47.

2. DiRenzo DM, et al. Cell Signal. 2016 May;28(5):498-505.

3. Ohashi W, et al. Biochem Biophys Res Commun. 2017 Nov 25;493(3):1342-1348.

SKL2001 (SKL 2001;SKL-2001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SKL2001 (SKL 2001;SKL-2001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.