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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-SKI-73
SKI-73

Chemical Structure : SKI-73

CAS No.: 2206744-61-6

SKI-73 (CARM1 inhibitor, SKI73)

货号: PC-73099Not For Human Use, Lab Use Only.

SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.

规格 价格 库存 数量
10 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.
    SKI-73 (10 uM) fully suppresses the methylation of BAF155 Arg1064 in MCF-7 cells.
    SKI-73 inhibits in vitro invasion but not proliferation of breast cancer cells ( MDA-MB-231 cell, EC50=1.3 uM).
    SKI-73 recapitulates the anti-invasion effect of the genetic perturbation of CARM1.
    Either CARM1 knockout or CARM1 inhibition with SKI-73 alters the epigenetic plasticity in a proliferation-independent manner by replacing the most invasion-prone subpopulation with the non-invasive subpopulation(s) to suppress the invasive phenotype.

    物理化学性质&存储条件

    分子量 851.018
    分子式 C46H58N8O8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2S,5S)-6-((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-((benzylamino)methyl)-N-(4-methoxyphenethyl)-2-(3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamido)hexanamide

    参考文献

    1. Xiao-Chuan Cai, et al. Elife. 2019 Oct 28;8:e47110.

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