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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Sphingosine kinase (SphK)-SKI-178
SKI-178

Chemical Structure : SKI-178

CAS No.: 1259484-97-3

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SKI-178 (SKI178)

货号: PC-61768Not For Human Use, Lab Use Only.

SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM).
SKI-178 induces apoptosis in human AML cell lines in a CDK1-dependent manner and is not a substrate for MDR1.
SKI-178 shows effectivity in mouse models of AML.

物理化学性质&存储条件

分子量 394.42
分子式 C21H22N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

参考文献

1. Hengst JA, et al. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7498-502.

2. Dick TE, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):494-508.

3. Hengst JA, et al. Cancer Transl Med. 2017 Jul-Aug;3(4):109-121.

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