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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-SKF 38393 hydrochloride
SKF 38393 hydrochloride

Chemical Structure : SKF 38393 hydrochloride

CAS No.: 62717-42-4

SKF 38393 hydrochloride ((±)-SKF-38393 hydrochloride;SKF-38393A)

货号: PC-43088Not For Human Use, Lab Use Only.

SKF 38393 is a potent, selective prototypical D1-like dopamine receptor with Ki of 1 and 0.5 nM for D1 and D5 receptors, shows little to no affinity for D2, D3 and D4 receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SKF 38393 is a potent, selective prototypical D1-like dopamine receptor with Ki of 1 and 0.5 nM for D1 and D5 receptors, shows little to no affinity for D2, D3 and D4 receptors; enhances the frequency of mEPSCs, and exhibits stimulant and anorectic effects, stimulates the release of glutamate in the hippocampus.

物理化学性质&存储条件

分子量 291.7726
分子式 C16H18ClNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 34 mg/mL

Chemical Name/SMILES

1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride (1:1)

参考文献

1. Geter-Douglass B, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):7-15.

2. Habuchi Y, et al. Br J Pharmacol. 1997 Dec;122(8):1669-78.

3. Sibley DR, et al. Life Sci. 1982 Aug 16;31(7):637-45.

4. Bouron A, et al. Neuroscience. 1999;94(4):1063-70.

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