SKF-96365 hydrochloride | SOCE inhibitor | Probechem Biochemicals

Chemical Structure : SKF-96365 hydrochloride

CAS No.: 130495-35-1

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SKF-96365 hydrochloride (SKF96365 hydrochloride)

货号: PC-42017Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

SKF-96365 hydrochloride (SKF96365) is potent inhibitor of receptor-mediated calcium entry (RMCE) with IC50 of 8.5 and 11.7 uM for inhibition in platelets stimulated with ADP and thrombin, respectively.
SKF-96365 shows selectivity in blocking RMCE compared with receptor-mediated internal Ca2+ release.
SKF-96365 inhibits Store-operated Ca2+ entry (SOCE) and Icrac in the 20-30 uM range in several cell lines, and inhibits STIM1-mediated Ca2+ influx and the nuclear translocation and activation of the NFAT transcription factor in cells expressing STIM1.
SKF-96365 also blocks TRPC, voltage gated Ca2+ channel (human Cav3.1 IC50= 560 nM), potassium channels.

物理化学性质&存储条件

分子量	402.9144
分子式	C22H27ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, hydrochloride (1:1)

参考文献

1. Merritt JE, et al. Biochem J. 1990 Oct 15;271(2):515-22.

2. Singh A, et al. Br J Pharmacol. 2010 Jul;160(6):1464-75.

3. Várnai P, et al. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.

SKF-96365 hydrochloride (SKF96365 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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SKF-96365 hydrochloride (SKF96365 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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