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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-GABA Transporter (GAT)-SKF-89976A hydrochloride
SKF-89976A hydrochloride

Chemical Structure : SKF-89976A hydrochloride

CAS No.: 85375-15-1

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SKF-89976A hydrochloride (SKF89976A hydrochloride)

货号: PC-42093Not For Human Use, Lab Use Only.

SKF-89976A hydrochloride is a potent, selective and GABA transporter 1 (GAT1) inhibitor with IC50 of 0.13 uM for hGAT1.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SKF-89976A hydrochloride is a potent, selective and GABA transporter 1 (GAT1) inhibitor with IC50 of 0.13 uM for hGAT1.
SKF-89976A shows little to no activity for rGAT-2, hGAT-3 and hBGT-1 (IC50>500 uM).
SKF-89976A blocks GABA uptake and uncoupled transmitter-gated current with Ki of 7 uM and 0.03 uM, respectively.

物理化学性质&存储条件

分子量 371.9003
分子式 C22H26ClNO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 34 mg/mL
Chemical Name/SMILES

3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)-, hydrochloride (1:1)

参考文献

1. Ali FE, et al. J Med Chem. 1985 May;28(5):653-60.

2. Stringer JL, et al. Epilepsy Res. 2002 Dec;52(2):129-37.

3. Krause S, et al. Mol Pharmacol. 2005 Dec;68(6):1728-35.

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