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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-SKF-86002
SKF-86002

Chemical Structure : SKF-86002

CAS No.: 72873-74-6

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SKF-86002 (SKF86002)

货号: PC-43080Not For Human Use, Lab Use Only.

SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM.

规格 价格 库存 数量
2 mg (Free Sample) ￥280 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SKF-86002 is a potent inhibitor of p38 MAPK with IC50 of 0.5-1 uM, inhibits LPS-induced IL-1 and TNF-α production in human monocyte with IC50 of 1 uM.
SKF-86002 inhibits prostaglandin H2 (PGH2) synthase activity (IC50=120 uM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50=70 uM).
SKF-86002 blocks superoxide anion production in response to FMLP and reduces adhesion and chemotaxis in response to PAF or FMLP in human neutrophils.
SKF-86002 also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50=10 and 100 uM respectively), shows anti-inflammatory in vivo.

物理化学性质&存储条件

分子量 297.35
分子式 C16H12FN3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Imidazo[2,1-b]thiazole, 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-

参考文献

1. Griswold DE, et al. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.

2. Nick JA, et al. J Clin Invest. 1997 Mar 1;99(5):975-86.

3. Lee JC, et al. Nature. 1994 Dec 22-29;372(6508):739-46.

4. Perregaux DG, et al. Mol Pharmacol. 1995 Sep;48(3):433-42.

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