SKA-31 | KCa2/KCa3.1 activator | Probechem Biochemicals

Chemical Structure : SKA-31

CAS No.: 40172-65-4

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SKA-31 (SKA31)

货号: PC-47099Not For Human Use, Lab Use Only.

SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

SKA-31 is a small molecule activator of KCa2 and KCa3.1 potassium channels with EC50 values of 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively.
SKA-31 activated native KCa2.3 and KCa3.1 channels in murine endothelial cells, and potentiated endothelium-derived hyperpolarizing factor-mediated dilations of carotid arteries from KCa3.1(+/+) mice but not from KCa3.1(-/-) mice.
Administration of 10 and 30 mg/kg SKA-31 lowered mean arterial blood pressure by 4 and 6 mm Hg in normotensive mice and by 12 mm Hg in angiotensin-II-induced hypertension.

物理化学性质&存储条件

分子量	200.259
分子式	C11H8N2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	naphtho[1,2-d]thiazol-2-ylamine

参考文献

1. Sankaranarayanan A, et al. Mol Pharmacol. 2009 Feb;75(2):281-95.

2. Parajuli SP, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):114-23.

SKA-31 (SKA31)

生物&药学活性

物理化学性质&存储条件

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SKA-31 (SKA31)

生物&药学活性

物理化学性质&存储条件

参考文献

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