SKA-121 |CAS:1820708-73-3 Probechem Biochemicals

Chemical Structure : SKA-121

CAS No.: 1820708-73-3

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SKA-121 (SKA 121;SKA121)

货号: PC-60780Not For Human Use, Lab Use Only.

SKA-121 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 109 nM.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

SKA-121 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 109 nM.
SKA-121 displays 41-fold selectivity over KCa2.3 (EC50=4.4 uM), and 200- to 400-fold selectivity over representative KV, NaV, as well as CaV1.2 channels.
SKA-121 significantly lowers mean arterial blood pressure in normotensive and hypertensive mice.

物理化学性质&存储条件

分子量	198.225
分子式	C12H10N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methylnaphtho[2,1-d]oxazol-2-amine

参考文献

1. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57.

2. Christophersen P, et al. Channels (Austin). 2015;9(6):336-43.

3. Oliván-Viguera A, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.

4. Brown BM, et al. Mol Pharmacol. 2017 Oct;92(4):469-480.

SKA-121 (SKA 121;SKA121)

生物&药学活性

物理化学性质&存储条件

参考文献

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SKA-121 (SKA 121;SKA121)

生物&药学活性

物理化学性质&存储条件

参考文献

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