SKA-111 |CAS:1369170-24-0 Probechem Biochemicals

Chemical Structure : SKA-111

CAS No.: 1369170-24-0

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SKA-111 (SKA 111;SKA111)

货号: PC-60781Not For Human Use, Lab Use Only.

SKA-111 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

SKA-111 is a potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM.
SKA-111 displays 123-fold selectivity over KCa2.3 (EC50=13.7 uM), and 200- to 400-fold selective over representative KV, NaV, as well as CaV1.2 channels.
SKA-111 not only lowers blood pressure but also drastically reduces heart rate, presumably through cardiac and neuronal KCa2 activation in mice.

物理化学性质&存储条件

分子量	214.286
分子式	C12H10N2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methylnaphtho[1,2-d]thiazol-2-amine

参考文献

1. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57.

2. Oliván-Viguera A, et al. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.

SKA-111 (SKA 111;SKA111)

生物&药学活性

物理化学性质&存储条件

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SKA-111 (SKA 111;SKA111)

生物&药学活性

物理化学性质&存储条件

参考文献

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