SK2 channel inhibitor Compound 1

Chemical Structure : SK2 channel inhibitor Compound 1

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货号: PC-25952Not For Human Use, Lab Use Only.

SK2 channel inhibitor Compound 1 is a potent, selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2) with IC50 of 69 nM, with 10-fold reduced potency for SK4 (IC50=660 nM), has high selectivity over other ion channels tested including hERG, Nav1.5, KCNQ1, and Cav1.2.

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物理化学性质&存储条件

分子量	424.43
分子式	C20H16N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(benzo[c][1,2,5]oxadiazol-4-yl)-3-((4-methoxyphenyl)sulfonamido)benzamide

参考文献

1. Cassell SJ, et al. Elife. 2025 Dec 4;14:RP107733.