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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Plasminogen Activator Inhibitor-1 (PAI-1)-SK-216
SK-216

Chemical Structure : SK-216

CAS No.: 654080-03-2

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SK-216 (SK 216, SK216)

货号: PC-61650Not For Human Use, Lab Use Only.

SK-216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SK-216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM.
    SK-216 reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model.
    SK-216 also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro.

    物理化学性质&存储条件

    分子量 533.52
    分子式 C29H29NO6Na2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt

    参考文献

    1. Masuda T, et al. Mol Cancer Ther. 2013 Nov;12(11):2378-88.

    2. Mutoh M, et al. Carcinogenesis. 2008 Apr;29(4):824-9.

    3. Takayama Y, et al. Cancer Res. 2016 Jun 1;76(11):3285-94.

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