SK-216 (SK216) | PAI-1 inhibitor | Probechem Biochemicals

Chemical Structure : SK-216

CAS No.: 654080-03-2

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SK-216 (SK 216, SK216)

货号: PC-61650Not For Human Use, Lab Use Only.

SK-216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

SK-216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM.
SK-216 reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model.
SK-216 also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro.

物理化学性质&存储条件

分子量	533.52
分子式	C29H29NO6Na2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt

参考文献

1. Masuda T, et al. Mol Cancer Ther. 2013 Nov;12(11):2378-88.

2. Mutoh M, et al. Carcinogenesis. 2008 Apr;29(4):824-9.

3. Takayama Y, et al. Cancer Res. 2016 Jun 1;76(11):3285-94.

SK-216 (SK 216, SK216)

生物&药学活性

物理化学性质&存储条件

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SK-216 (SK 216, SK216)

生物&药学活性

物理化学性质&存储条件

参考文献

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