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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Pregnane X Receptor (PXR)-SJPYT-331
SJPYT-331

Chemical Structure : SJPYT-331

CAS No.: 2998548-65-3

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SJPYT-331 (SJPYT331)

货号: PC-22401Not For Human Use, Lab Use Only.

SJPYT-331 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 3.6 nM, antagonistic IC50 of 7.1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SJPYT-331 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 3.6 nM, antagonistic IC50 of 7.1 nM.
SJPYT-331 blocks agonist-induced PXR activation in primary human hepatocytes (PHH).

物理化学性质&存储条件

分子量 496.56
分子式 C26H32N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (S)-3-(1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamido)-4-(hexan-3-yloxy)benzoate

参考文献

1. Garcia-Maldonado E, et al. Nat Commun. 2024 May 14;15(1):4054.

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