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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Pregnane X Receptor (PXR)-SJPYT-318
SJPYT-318

Chemical Structure : SJPYT-318

CAS No.:

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SJPYT-318 (SJPYT318)

货号: PC-21198Not For Human Use, Lab Use Only.

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SJPYT-318 is a highly selective pregnane X receptor (PXR) agonist, targets PXR ligand-binding domain (LBD), exhibits selectivity for PXR LBD over LXR LBDs for recruiting SRC-1.
SJPYT-318 is strongly selective for PXR in cellular reporter activation, showing only marginal activation of both LXRα and LXRβ.

物理化学性质&存储条件

分子量 581.53
分子式 C28H21F6NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(4-phenoxybenzyl)benzenesulfonamide

参考文献

1. Huber AD, et al. Structure. 2023 Sep 5:S0969-2126(23)00297-6.

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