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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Pregnane X Receptor (PXR)-SJPYT-310
SJPYT-310

Chemical Structure : SJPYT-310

CAS No.: 2883814-84-2

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SJPYT-310 (SJPYT310)

货号: PC-22399Not For Human Use, Lab Use Only.

SJPYT-310 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 4 nM, antagonistic IC50 of 9 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SJPYT-310 is a potent, selective pregnane X receptor (PXR) antagonist with binding IC50 of 4 nM, antagonistic IC50 of 9 nM.
SJPYT-310 is selective for hPXR without affecting the activity of mPXR, hCAR, hFXR, hLXRα, or hVDR.
SJPYT-310 shows only marginal cytotoxicity in the cell models used (HepG2 and HEK293), and in hepatoma cells Hepa 1–6 and HepaRG.

物理化学性质&存储条件

分子量 464.61
分子式 C27H36N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(5-(tert-butyl)-2-(pentan-2-yloxy)phenyl)-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

参考文献

1. Garcia-Maldonado E, et al. Nat Commun. 2024 May 14;15(1):4054.

2. Yongtao Li, et al. J Med Chem. 2022 Dec 22;65(24):16829-16859.

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