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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Pregnane X Receptor (PXR)-SJPYT-306
SJPYT-306

Chemical Structure : SJPYT-306

CAS No.: 2883814-80-8

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SJPYT-306 (SJPYT306)

货号: PC-22400Not For Human Use, Lab Use Only.

SJPYT-306 is a potent, selective dual antagonist and inverse agonist of pregnane X receptor (PXR) with binding IC50 of 6 nM, inverse agonist and antagonist IC50 of 1 nM and 14 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SJPYT-306 is a potent, selective dual antagonist and inverse agonist of pregnane X receptor (PXR) with binding IC50 of 6 nM, inverse agonist and antagonist IC50 of 1 nM and 14 nM, respectively.

物理化学性质&存储条件

分子量 480.61
分子式 C27H36N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(5-(tert-butyl)-2-(pentan-2-yloxy)phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide

参考文献

1. Yongtao Li, et al. J Med Chem. 2022 Dec 22;65(24):16829-16859.

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