SJB2-043 | USP1 inhibitor | Probechem Biochemicals

Chemical Structure : SJB2-043

CAS No.: 63388-44-3

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SJB2-043 (USP1 inhibitor)

货号: PC-73197Not For Human Use, Lab Use Only.

SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

SJB2-043 is a small molecule, specific USP1 inhibitor, inhibits USP1/UAF1 complex with IC50 of 0.544 uM.
SJB2-043 is an inhibitor of the native USP1/UAF1 complex.
SJB2-043 promotes ID1 degradation and inhibits growth of the leukemic cell line K562, also causes a decrease in the levels of other ID proteins, namely ID2 and ID3.
SJB2-043 causes cytotoxicity in multiple AML cell line K562 with EC50 of 1.07 uM, and exhibits growth inhibition of primary AML cells from patients.
SJB2-043 increases the levels of Ub-FANCD2, decreases the HR activity, and sensitizes the cells to chemotherapy agents.
SJB2-043 also inhibits SARS-CoV-2 papain-like protease (PLpro) with IC50 of <10 uM.

物理化学性质&存储条件

分子量	275.26
分子式	C17H9NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Phenylnaphtho[2,3-d]oxazole-4,9-dione

参考文献

1. Mistry H, et al. Mol Cancer Ther. 2013 Dec;12(12):2651-62.

2. Chia-Chuan Cho, et al. ChemMedChem. 2022 Jan 5;17(1):e202100455.

SJB2-043 (USP1 inhibitor)

生物&药学活性

物理化学性质&存储条件

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SJB2-043 (USP1 inhibitor)

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