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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-SJ1461
SJ1461

Chemical Structure : SJ1461

CAS No.: 2924546-70-1

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SJ1461 (SJ-1461)

货号: PC-20312Not For Human Use, Lab Use Only.

SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SJ1461 (SJ-1461) is a potent and orally bioavailable BET inhibitor with IC50 of 6.8/0.2 nM for BRD4 BD1/BD2, and 1.3/0.1 nM for BRD2 BD1/BD2, respectively.
    SJ1461 displays high potency in the panel of acute leukaemia and medulloblastoma cell lines.

    物理化学性质&存储条件

    分子量 483.99
    分子式 C21H18ClN7OS2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(1,3,4-thiadiazol-2-yl)acetamide

    参考文献

    1. Mladen Koravovic, et al. Eur J Med Chem. 2023 Mar 4;251:115246.

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