SIS17 | HDAC11 inhibitor | Probechem Biochemicals

Chemical Structure : SIS17

CAS No.: 2374313-54-7

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SIS17 (HDAC11 inhibitor SIS17)

货号: PC-72097Not For Human Use, Lab Use Only.

SIS17 is a selective, cell-active HDAC11 inhibitor with IC50 of 0.83 uM.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg	￥5280	In stock
250 mg		Get quote

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生物&药学活性

SIS17 is a selective, cell-active HDAC11 inhibitor with IC50 of 0.83 uM.
SIS17 displays no inhibitory effect (IC50>100 uM) against Class I (HDAC1 and HDAC8), Class II (HDAC4), and the NAD-dependent Class III (sirtuins, SIRT1, SIRT2, SIRT3, and SIRT6).
SIS17 inhibits the demyristoylation of a myristoyl-SHMT2 peptide by HDAC11 in vitro with IC50 of 270 nM, inhibits HDAC11-mediated SHMT2 defatty-acylation in cells.

物理化学性质&存储条件

分子量	366.608
分子式	C21H38N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-hexadecylthiophene-2-carbohydrazide

参考文献

1. Se In Son, et al. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397.

SIS17 (HDAC11 inhibitor SIS17)

生物&药学活性

物理化学性质&存储条件

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SIS17 (HDAC11 inhibitor SIS17)

生物&药学活性

物理化学性质&存储条件

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