SIRT7 inhibitor 97491 | SIRT7 inhibitor | Probechem Biochemicals

Chemical Structure : SIRT7 inhibitor 97491

CAS No.: 1807758-81-1

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SIRT7 inhibitor 97491 (ID 97491)

货号: PC-38461Not For Human Use, Lab Use Only.

SIRT7 inhibitor 97491 is a novel specific inhibitor of SIRT7 with IC50 of 0.325 uM, reduces deacetylase activity of SIRT7 in a dose-dependent manner.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SIRT7 inhibitor 97491 is a novel specific inhibitor of SIRT7 with IC50 of 0.325 uM, reduces deacetylase activity of SIRT7 in a dose-dependent manner.
SIRT7 inhibitor 97491 inhibits cell proliferation of uterine sarcoma MES-SA cells with IC50 of < 5 uM.
SIRT7 inhibitor 97491 induces p53 acetylation at lysine 373/382 and increases p53 phosphorylation at S392 in treated MES-SA cells (24 h).
SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway and suppresses MES-SA tumor growth in nude mice (20 mg/kg/day, i.p.).

物理化学性质&存储条件

分子量	285.73
分子式	C15H12ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-[5-(4-Chlorophenyl)-2-oxazolyl]-1,3-benzenediamine

参考文献

1. Ji-Hye Kim, et al. Identification of a novel SIRT7 inhibitor as anticancer drug candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

SIRT7 inhibitor 97491 (ID 97491)

生物&药学活性

物理化学性质&存储条件

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SIRT7 inhibitor 97491 (ID 97491)

生物&药学活性

物理化学性质&存储条件

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