SIRT6 inhibitor S6 | SIRT6 inhibitor | Probechem Biochemicals

Chemical Structure : SIRT6 inhibitor S6

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SIRT6 inhibitor S6 (SIRT6-IN-1, PubChem CID 46966788)

货号: PC-21890Not For Human Use, Lab Use Only.

SIRT6 inhibitor S6 (SIRT6-IN-1) is a selective SIRT6 inhibitor with IC50 of 106 nM, 114 nM and 314 nM for SIRT6, SIRT2 and SIRT1 respectively.

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生物&药学活性

SIRT6 inhibitor S6 (SIRT6-IN-1) is a selective SIRT6 inhibitor with IC50 of 106 uM, 114 uM and 314 uM for SIRT6, SIRT2 and SIRT1 respectively.
SIRT6 inhibitor S6 increases acetylation at SIRT6 target lysines on histone 3, reduces TNF-α secretion, GLUT-1 upregulation, and increases glucose uptake.

物理化学性质&存储条件

分子量	410.40
分子式	C19H14N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Dioxo-N-[4-(pyridin-3-yloxy)phenyl]-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

参考文献

1. Elena Abbotto, et al. Biomed Pharmacother. 2023 Oct:166:115326.

SIRT6 inhibitor S6 (SIRT6-IN-1, PubChem CID 46966788)

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物理化学性质&存储条件

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SIRT6 inhibitor S6 (SIRT6-IN-1, PubChem CID 46966788)

生物&药学活性

物理化学性质&存储条件

参考文献

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