SIRT6 inhibitor 10d

Chemical Structure : SIRT6 inhibitor 10d

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货号: PC-23601Not For Human Use, Lab Use Only.

SIRT6 inhibitor 10d is a potent, selective competitive SIRT6 inhibitor, effectively inhibits the deacetylation activity of SIRT6 on fluorescent acetyl substrate Ac-RHKK(Ac)-AMC with IC50 of 5.8 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

SIRT6 inhibitor 10d is a potent, selective competitive SIRT6 inhibitor, effectively inhibits the deacetylation activity of SIRT6 on fluorescent acetyl substrate Ac-RHKK(Ac)-AMC with IC50 of 5.8 uM.
SIRT6 inhibitor 10d displays >27-fold selective over other SIRTs.
SIRT6 inhibitor 10d inhibits the proliferation of MCF-7 cells in a dose-dependent manner, with an IC50 of 8.3 uM.
SIRT6 inhibitor 10d (20 uM) inhibits the deacetylation activity of SIRT6 in breast cancer MCF-7 cells.
SIRT6 inhibitor 10d (5-20 uM) inhibits the proliferation, migration, and invasion of breast cancer MCF-7 cells, blocks the DNA damage repair pathway in breast cancer and promotes apoptosis.
SIRT6 inhibitor 10d (10, 20, and 40 mg/kg) exhibits antibreast cancer activity in mice bearing 4T1 tumor graft.

物理化学性质&存储条件

分子量	451.91
分子式	C26H18ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Chloro-9-(4-cyanobenzyl)-N-(pyridin-2-ylmethyl)-9H-pyrido[3,4-b]indole-3-carboxamide

参考文献

1. Liang C, et al. J Med Chem. 2024 Dec 4. doi: 10.1021/acs.jmedchem.4c01921.