SIRT6 activator 12q | SIRT6 activator | Probechem Biochemicals

Chemical Structure : SIRT6 activator 12q

CAS No.: 2601734-99-8

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SIRT6 activator 12q (Compound 12q)

货号: PC-38584Not For Human Use, Lab Use Only.

SIRT6 activator 12q (Compound 12q) is a potent, selective SIRT6 activator with EC1.5 value of 0.58 μM and EC50 value of 5.35 μM against SIRT6-dependent peptide deacetylation in FLUOR DE LYS assay.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

SIRT6 activator 12q (Compound 12q) is a potent, selective SIRT6 activator with EC1.5 value of 0.58 μM and EC50 value of 5.35 μM against SIRT6-dependent peptide deacetylation in FLUOR DE LYS assay.
SIRT6 activator 12q exhibited weak or no activity against other HDAC family members as well as 415 kinases.
SIRT6 activator 12q significantly inhibited the proliferation and migration of pancreatic ductal adenocarcinoma (PDAC) cells in vitro.
SIRT6 activator 12q markedly suppressed the tumor growth in a PDAC tumor xenograft model.

物理化学性质&存储条件

分子量	454.529
分子式	C31H22N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-benzofuran-2-yl)-N-(diphenylmethyl) quinoline-4-carboxamide

参考文献

1. Xiuli Chen, et al. J Med Chem. 2020 Sep 24;63(18):10474-10495.

SIRT6 activator 12q (Compound 12q)

生物&药学活性

物理化学性质&存储条件

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SIRT6 activator 12q (Compound 12q)

生物&药学活性

物理化学性质&存储条件

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