SIRT3 activator MY-13 | SIRT3 activator | Probechem Biochemicals

Chemical Structure : SIRT3 activator MY-13

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SIRT3 activator MY-13 (MY-13)

货号: PC-22069Not For Human Use, Lab Use Only.

SIRT3 activator MY-13 is a small-molecule activator of SIRT3, inhibits CRC cell proliferation and migration.

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生物&药学活性

SIRT3 activator MY-13 is a small-molecule activator of SIRT3, inhibits CRC cell proliferation and migration.
MY-13 inhibits colorectal cancer cell growth in vitro with IC50 of 5.23 μM in RKO cells and 14.71 μM in HCT-116 cells.
MY-13 (40, 80 mg.kg) effectively inhibits the growth of colorectal cancer in vivo without apparent systemic toxicity.
MY-13 (10 uM) attenuates colorectal cancer cell migration in vitro, induces autophagy-dependent cell death in CRC.
MY-13 inhibits proliferation and migration via the SIRT3/Hsp90/AKT pathway in CRC.

物理化学性质&存储条件

分子量	317.33
分子式	C18H12FN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carbonitrile

参考文献

1. Mou Y, et al. Bioorg Chem. 2024 Apr 2;146:107327.

SIRT3 activator MY-13 (MY-13)

生物&药学活性

物理化学性质&存储条件

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SIRT3 activator MY-13 (MY-13)

生物&药学活性

物理化学性质&存储条件

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