SIRT2 inhibitor 33a

Chemical Structure : SIRT2 inhibitor 33a

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货号: PC-21146Not For Human Use, Lab Use Only.

SIRT2 inhibitor 33a is a potent, specific Sirtuin 2 (SIRT2) inhibitor with IC50 of 1.0 uM, no activity against SIRT1 and SIRT3 (IC50>100 uM).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

SIRT2 inhibitor 33a is a potent, specific Sirtuin 2 (SIRT2) inhibitor with IC50 of 1.0 uM, no activity against SIRT1 and SIRT3 (IC50>100 uM).
SIRT2 inhibitor 33a induces a dose-dependent selective increase of α-tubulin acetylation in human colon cancer HCT116 cells.

物理化学性质&存储条件

分子量	332.40
分子式	C21H20N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N)C1=CC=CC=C1NC2=CC=CC(OCCC3=CC=CC=C3)=C2

参考文献

1. Takayoshi Suzuki, et al. J Med Chem. 2012 Jun 28;55(12):5760-73.