SIMM-036 | SARS-CoV-2 PLpro inhibitor | Probechem Biochemicals

Chemical Structure : SIMM-036

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SIMM-036 (SIMM036)

货号: PC-22611Not For Human Use, Lab Use Only.

SIMM-036 is a specific small molecule SARS-CoV-1 PLpro inhibitor with IC50 of 192.3 nM, inhibits the K63-deubiquitinase activity of SARS-CoV-2 Plpro.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

SIMM-036 is a specific small molecule SARS-CoV-1 PLpro inhibitor with IC50 of 192.3 nM, inhibits the K63-deubiquitinase activity of SARS-CoV-2 Plpro.
SIMM-036 does not inhibits host deubiquitinase activities (USP1, USP7 and USP28).
SIMM-036 potently blocks the PLpro mediated deubiquitinase activity against K63-linked polyUb4 chain with the IC50 value of 10.48 uM, more potent than GRL-0617.
SIMM-036 (10 uM) significantly inhibits PLpro-mediated viral replication activity, protects the RLR mediated interferon response from the K63-deubiquitinase activity of SARS-CoV-2 PLpro.

物理化学性质&存储条件

分子量	532.68
分子式	C29H33FN6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((4-fluorobenzyl)thio)-4H-imidazo[4,5-b]pyridin-4-yl)-N-(2-methyl-5-(piperidin-4-ylamino)phenyl)butanamide

参考文献

1. Xin Liu, et al. Antiviral Res. 2024 Jun 22:228:105944.

SIMM-036 (SIMM036)

生物&药学活性

物理化学性质&存储条件

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SIMM-036 (SIMM036)

生物&药学活性

物理化学性质&存储条件

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