SIK inhibitor M22

Chemical Structure : SIK inhibitor M22

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货号: PC-20809Not For Human Use, Lab Use Only.

SIK inhibitor M22 is a potent, selective pan-SIK (salt-inducible kinase) with IC50 of 72, 89 and 18 nM for SIK1, SIK2 and SIK3 in NanoBERT assays, respectively.

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1 g		Get quote

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生物&药学活性

SIK inhibitor M22 is a potent, selective pan-SIK (salt-inducible kinase) with IC50 of 72, 89 and 18 nM for SIK1, SIK2 and SIK3 in NanoBERT assays, respectively.
SIK inhibitor M22 displays excellent selectivity in a representative kinase panel, including STE group kinases.
SIK inhibitor M22 treatment caused centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells, as observed with MRIA9 (Cat. PC-72723), conclusively linking these phenotypic effects to SIK inhibition.
MR22 is a valuable tool compound for studying SIK kinase function in cells.

物理化学性质&存储条件

分子量	359.38
分子式	C18H19F2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1C(C2=CC(F)=CC=C2F)=CC3=CN=C(NC)N=C3N1CCCCN

参考文献

1. Rak M, et al. Eur J Med Chem. 2023 Jun 5;254:115347.