SIH-001 | ZMIZ1 inhibitor | Probechem Biochemicals

Chemical Structure : SIH-001

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SIH-001 (SIH001)

货号: PC-26881Not For Human Use, Lab Use Only.

SIH-001 is a specific small-molecule inhibitor of ZMIZ1 (Zinc finger MIZ domain-containing protein 1) with SPR KD of 0.498 uM.

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生物&药学活性

SIH-001 is a specific small-molecule inhibitor of ZMIZ1 (Zinc finger MIZ domain-containing protein 1) with SPR KD of 0.498 uM.
SIH-001 selectively reduces the intracellular stability of ZMIZ1, while exerting no detectable effects on other ZMIZ family proteins.
SIH-001 induces effective suppression of ZMIZ1 chromatin association in OCI-AML3 and MOLM-13 cells.
SIH-001 markedly potentiates AML cell differentiation and/or apoptosis induced by the menin inhibitor ziftomenib and the BCL2 inhibitor venetoclax, respectively.
SIH-001 downregulates DNA-replication and stemness-related programs and upregulated hematopoietic and antigen-presentation/surface-receptor signaling pathways.
SIH-001 significantly prolonged the survival of AML-bearing mice in both the murine AML model and AML organoids.

物理化学性质&存储条件

分子量	366.48
分子式	C21H22N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl)-1-(thiophen-2-yl)cyclopentane-1-carboxamide

参考文献

1. Li H, et al. Signal Transduct Target Ther. 2026 May 19;11(1):189.

SIH-001 (SIH001)

生物&药学活性

物理化学性质&存储条件

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SIH-001 (SIH001)

生物&药学活性

物理化学性质&存储条件

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