SID7969543 | SF-1/NR5A1 inhibitor | Probechem Biochemicals

Chemical Structure : SID7969543

CAS No.: 868224-64-0

加入收藏

SID7969543 (SID 7969543)

货号: PC-72819Not For Human Use, Lab Use Only.

SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells.

规格	价格	库存
5 mg	￥2280	In stock
10 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells.
SID7969543 limited the viability of 7 out of 11 KMT2A-r leukemia cell lines including 5 out of 7 lines derived from infants, without affecting KMT2A-wt leukemia cells, solid cancer lines, non-malignant cell lines, or peripheral blood mononuclear cells from healthy controls.
SID7969543 decreased KMT2A-r leukemia cell viability by inducing caspase-dependent apoptosis within hours of treatment and demonstrated synergy with established chemotherapeutics used in the treatment of high-risk leukemia.

物理化学性质&存储条件

分子量	452.46
分子式	C24H24N2O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate

参考文献

1. Madoux F, et al. Mol Pharmacol. 2008 Jun;73(6):1776-84.

2. Karsa M, et al. Front Oncol. 2022 Jan 20;11:779859.

SID7969543 (SID 7969543)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SID7969543 (SID 7969543)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.