SID 26681509 | Cathepsin L inhibitor | Probechem Biochemicals

Chemical Structure : SID 26681509

CAS No.: 958772-66-2

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SID 26681509 (SID26681509)

货号: PC-38582Not For Human Use, Lab Use Only.

SID 26681509 is a potent, selective inhibitor of lysosome hydrolase cathepsin L with IC50 of 56 nM, displays no inhibitory activity at cathepsin G.

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5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3980	In stock
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100 mg		Get quote

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生物&药学活性

SID 26681509 is a potent, selective inhibitor of lysosome hydrolase cathepsin L with IC50 of 56 nM, displays no inhibitory activity at cathepsin G.
SID 26681509 displays 7- to 151-fold greater selectivity toward cathepsin L than papain and cathepsins B, K, V, and S.
SID 26681509 demonstrated a lack of toxicity in human aortic endothelial cells and zebrafish.
SID 26681509 inhibited in vitro propagation of malaria parasite Plasmodium falciparum with IC50 of 15.4 microM and inhibited Leishmania major with IC50 of 12.5 microM.

物理化学性质&存储条件

分子量	539.651
分子式	C27H33N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan 2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide

参考文献

1. Shah PP, et al. Mol Pharmacol. 2008 Jul;74(1):34-41.

2. Campbell GR, et al. PLoS Pathog. 2012;8(5):e1002689.

SID 26681509 (SID26681509)

生物&药学活性

物理化学性质&存储条件

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SID 26681509 (SID26681509)

生物&药学活性

物理化学性质&存储条件

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