SI409-1

Chemical Structure : SI409-1

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货号: PC-27990Not For Human Use, Lab Use Only.

SI409-1 is a specific small molecule inhibitor of dihydrolipoamide S-succinyltransferase (DLST) lysine 409 (K409), effectively inhibits DLST K409 succinylation (K409succ).

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

SI409-1 is a specific small molecule inhibitor of dihydrolipoamide S-succinyltransferase (DLST) lysine 409 (K409), effectively inhibits DLST K409 succinylation (K409succ).
Dihydrolipoamide S-succinyltransferase (DLST) is the E2 subunit of the α-ketoglutarate dehydrogenase complex (KGDHC) in the TCA cycle.
SI409-1 significantly inhibits DLST K409succ in lung adenocarcinoma (LUAD) cells without altering the global cellular succinylation level.
SI409-1 can inhibit the malignant progression of LUAD cells by suppressing DLST K409succ.
SI409-1 enhances the sensitivity of LUAD to cuproptosis and significantly inhibits the malignant progression of LUAD.

物理化学性质&存储条件

分子量	387.29
分子式	C20H30BN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-((3S,4R)-3-(4-acetyl-1,4-diazepan-1-yl)-4-methylpyrrolidine-1-carbonyl)-2-methylphenyl)boronic acid

参考文献

1. Xuanxuan Li, et al. Adv Sci (Weinh). 2026 Aug 30:e77528.

SI409-1

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物理化学性质&存储条件

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SI409-1

生物&药学活性

物理化学性质&存储条件

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