SI-113 | SGK1 inhibitor | ProbeChem Biochemicals

Chemical Structure : SI-113

CAS No.: 1392816-46-4

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SI-113 (SI113, SI 113)

货号: PC-70209Not For Human Use, Lab Use Only.

SI-113 (SI 113) is a potent, specific inhibitor of the SGK1 kinase activity with IC50 of 600 nM, induces autophagy, apoptosis and ER stress in cancer cells.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

SI-113 (SI 113) is a potent, specific inhibitor of the SGK1 kinase activity with IC50 of 600 nM, induces autophagy, apoptosis and ER stress in cancer cells.
SI-113 blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells.
SI-113 potentiates the effects of paclitaxel on cell viability; active in vivo.

物理化学性质&存储条件

分子量	400.486
分子式	C23H24N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(phenethylamino)-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)ethan-1-ol

参考文献

1. D'Antona L, et al. Cell Physiol Biochem. 2015;35(5):2006-18.

2. Talarico C, et al. Oncotarget. 2015 Nov 10;6(35):37511-25.

3. Talarico C, et al. Oncotarget. 2016 Mar 29;7(13):15868-84.

4. Radi M, et al. J Med Chem. 2011 Apr 28;54(8):2610-26.

SI-113 (SI113, SI 113)

生物&药学活性

物理化学性质&存储条件

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SI-113 (SI113, SI 113)

生物&药学活性

物理化学性质&存储条件

参考文献

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