SHR902275 | RAFinhibitor | Probechem Biochemicals

Chemical Structure : SHR902275

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SHR902275 (SHR 902275)

货号: PC-21592Not For Human Use, Lab Use Only.

SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAS mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively.

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生物&药学活性

SHR902275 is a potent, selective, and orally active RAF inhibitor targeting RAF mutants with IC50 of 1.6 nM, 10 nM, and 5.7 nM for cRAF, bRAFwt, and bRAFV600E, respectively.
SHR902275 exhibits cell growth inhibition with GI50s of 1.5 and 0.17 nM, 0.4 nM and 0.32 nM for H358, A375, Calu6, and SK-MEL2 cells respectively.
SHR902275 demonstrates dose dependent efficacy in in vivo RAS mutant Calu6 xenograft mouse model.

物理化学性质&存储条件

分子量	514.51
分子式	C26H25F3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methyl-3-(4-oxo-2',3',4,5,5',6',8,9-octahydro-3H-spiro[benzo[b][1,4]oxazepine-2,4'-pyran]-8-yl)phenyl)-5-(trifluoromethyl)pyridazine-3-carboxamide

参考文献

1. Peng Zhao, et al. Eur J Med Chem. 2022 Jan 15:228:114040.

SHR902275 (SHR 902275)

生物&药学活性

物理化学性质&存储条件

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SHR902275 (SHR 902275)

生物&药学活性

物理化学性质&存储条件

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