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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-SHR3824
SHR3824

Chemical Structure : SHR3824

CAS No.: 1623804-44-3

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SHR3824 (Henagliflozin, SHR-3824)

货号: PC-63374Not For Human Use, Lab Use Only.

SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.

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10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.
SHR3824 exhibits antidiabetic efficacy in several rodent models.

物理化学性质&存储条件

分子量 454.875
分子式 C22H24ClFO7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,2S,3S,4R,5R)-5-(4-Chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

参考文献

1. Yan PK, et al. Acta Pharmacol Sin. 2014 May;35(5):613-24. doi: 10.1038/aps.2013.196.

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