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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-SHR3824
SHR3824

Chemical Structure : SHR3824

CAS No.: 1358579-22-2

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SHR3824 (Henagliflozin, SHR-3824)

货号: PC-63374Not For Human Use, Lab Use Only.

SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SHR3824 (Henagliflozin) is a potent, selective SGLT2 inhibitor with IC50 of 2.38 nM, >1000-fold selectivity over SGLT1.
    SHR3824 exhibits antidiabetic efficacy in several rodent models.

    物理化学性质&存储条件

    分子量 454.875
    分子式 C22H24ClFO7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2S,3S,4R,5R)-5-(4-Chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

    参考文献

    1. Yan PK, et al. Acta Pharmacol Sin. 2014 May;35(5):613-24. doi: 10.1038/aps.2013.196.

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