SHR170008 | CD73 inhibitor | Probechem Biochemicals

Chemical Structure : SHR170008

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SHR170008 (SHR 170008)

货号: PC-72270Not For Human Use, Lab Use Only.

SHR170008 is a highly potent, small molecule CD73 inhibitor with IC50 of 0.05 nM against human CD73 soluble enzyme.

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100 mg		Get quote

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生物&药学活性

SHR170008 is a highly potent, small molecule CD73 inhibitor with IC50 of 0.05 nM against human CD73 soluble enzyme.
SHR170008 inhibits endogenous membrane-bound CD73 using CD73-expressing human melanoma cell line A375 with IC50 of 0.051 nM, much stronger than AMPCP (CI50=16 nM).
SHR170008 reverses the inhibitory effect of adenosine from AMP in the activation and proliferation of CD8+ T cells as well as Granzyme B+ cells in CD8+ cells.
SHR170008 significantly reverses the suppression of IFNγ production with average EC50=110 ± 51 nM in human PBMC.
SHR170008 exhibited in vivo anti-tumor efficacy and synergistic effects in combination with anti-PD-1 mAb in EMT6 mouse syngeneic breast tumor model.

物理化学性质&存储条件

分子量	537.894
分子式	C22H25ClN5O7P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((((2R,3S,4R,5R)-5-(6-chloro-4-(2',3'-dihydrospiro[azetidine-3,1'-inden]-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)phosphonic acid

参考文献

1. Suxing Liu, et al. Onco Targets Ther. 2021 Aug 24;14:4561-4574.

SHR170008 (SHR 170008)

生物&药学活性

物理化学性质&存储条件

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SHR170008 (SHR 170008)

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物理化学性质&存储条件

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