SHP844 |CAS: 2222280-82-0 Probechem Biochemicals

Chemical Structure : SHP844

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SHP844 (SHP 844)

货号: PC-62629Not For Human Use, Lab Use Only.

SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

SHP844 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 18.9 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
SHP844 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.
SHP844 enhances pharmacological pathway inhibition in cells combined with SHP099.

物理化学性质&存储条件

分子量	573.99
分子式	C29H24ClN5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-chloro-4-((1-(2-hydroxy-3-methoxyphenyl)-5-oxo-[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl)methyl)benzoyl)-L-proline

参考文献

1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.

SHP844 (SHP 844)

生物&药学活性

物理化学性质&存储条件

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SHP844 (SHP 844)

生物&药学活性

物理化学性质&存储条件

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