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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-SHP836
SHP836

Chemical Structure : SHP836

CAS No.: 1957276-35-5

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SHP836 (SHP 836)

货号: PC-62631Not For Human Use, Lab Use Only.

SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

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SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
SHP836 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells。
SHP836 enhances pharmacological pathway inhibition in cells combined with SHP099.

物理化学性质&存储条件

分子量 352.263
分子式 C16H19Cl2N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(2,3-dichlorophenyl)-2-((3S,5R)-3,5-dimethylpiperazin-1-yl)pyrimidin-4-amine

参考文献

1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.

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