SHP389 |CAS:2235394-90-6 Probechem Biochemicals

Chemical Structure : SHP389

CAS No.: 2235394-90-6

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SHP389 (SHP-389;SHP 389)

货号: PC-36050Not For Human Use, Lab Use Only.

SHP389 (SHP-389, SHP 389) is a novel potent, selective, allosteric SHP2 inhibitor with IC50 of 36 nM, shows with impressive hERG selectivity (IC50>30 uM).

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5 mg	￥4280	In stock
10 mg	￥7280	In stock
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生物&药学活性

SHP389 (SHP-389, SHP 389) is a novel potent, selective, allosteric SHP2 inhibitor with IC50 of 36 nM, shows with impressive hERG selectivity (IC50>30 uM).
SHP389 inhibits p-ERK in KYSE-520 cells with IC50 of 36 nM, and shows antiproliferation effect with IC50 of 0.36 uM.
SHP389 demonstrated a moderate-high clearance ~83% hepatic extraction) which was under predicted in vitro by rat liver microsomes (Cl= 26.1 uL/min/mg, T1/2 = 53.2 min) assuming a hepatic blood flow of 55 mL/min/kg.
SHP389 also showed low oral bioavailability (~2 %F).

物理化学性质&存储条件

分子量	484.989
分子式	C23H29ClN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(3-chloro-2-(cyclopropylamino)pyridin-4-yl)-5-methyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

参考文献

1. Bagdanoff JT, et al. J Med Chem. 2019 Feb 8. doi: 10.1021/acs.jmedchem.8b01725.

SHP389 (SHP-389;SHP 389)

生物&药学活性

物理化学性质&存储条件

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SHP389 (SHP-389;SHP 389)

生物&药学活性

物理化学性质&存储条件

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