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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-SHP2 inhibitor 9
SHP2 inhibitor 9

Chemical Structure : SHP2 inhibitor 9

CAS No.: 2055758-04-6

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SHP2 inhibitor 9

货号: PC-36040Not For Human Use, Lab Use Only.

SHP2 inhibitor 9 is a potent, selective inhibitor of SHP2 with IC50 of 48 nM, inhibits p-ERK in KYSE520 cells with IC50 of 28 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SHP2 inhibitor 9 is a potent, selective inhibitor of SHP2 with IC50 of 48 nM, inhibits p-ERK in KYSE520 cells with IC50 of 28 nM.
    SHP2 inhibitor 9 demonstrates antiproliferation activity in the EGFR amplified human esophageal squamous cell carcinoma cell line KYSE520 (IC50=220 nM), inhibits p-ERK and DUSP6.

    物理化学性质&存储条件

    分子量 450.99
    分子式 C20H27ClN6O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-((3-chloro-2-methylpyridin-4-yl)thio)-3-methylpyrimidin-4(3H)-one

    参考文献

    1. Sarver P, et al. J Med Chem. 2019 Jan 28. doi: 10.1021/acs.jmedchem.8b01726.

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