SHP2 inhibitor 8 |CAS: 2055757-51-0 Probechem Biochemicals

Chemical Structure : SHP2 inhibitor 8

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SHP2 inhibitor 8

货号: PC-36039Not For Human Use, Lab Use Only.

SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM.

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生物&药学活性

SHP2 inhibitor 8 is a potent, selective inhibitor of SHP2 with IC50 of 5 nM, inhibits p-ERK in KYSE520 cells with IC50 of 5 nM.
SHP2 inhibitor 8 demonstrates antiproliferation activity in the EGFR amplified human esophageal squamous cell carcinoma cell line KYSE520 (IC50=69 nM).
SHP2 inhibitor 8 also inhibits Detroit-562 pharyngeal carcinoma cell line in vitro with IC50 of 1.38 uM.
SHP2 inhibitor 8 inhibits p-ERK and DUSP6, shows efficacy in KYSE520 tumor implanted immunocompromised mice.

物理化学性质&存储条件

分子量	470.41
分子式	C20H25Cl2N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-((2,3-dichlorophenyl)thio)-3-methylpyrimidin-4(3H)-one

参考文献

1. Sarver P, et al. J Med Chem. 2019 Jan 28. doi: 10.1021/acs.jmedchem.8b01726.

SHP2 inhibitor 8

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物理化学性质&存储条件

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SHP2 inhibitor 8

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