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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-SHP2 inhibitor 2
SHP2 inhibitor 2

Chemical Structure : SHP2 inhibitor 2

CAS No.: 1799604-71-9

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SHP2 inhibitor 2

货号: PC-61273Not For Human Use, Lab Use Only.

SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SHP2 inhibitor 2 is a nove potent, selective and reversible SHP2 inhibitor with Ki of 0.51 uM.
    SHP2 inhibitor 2 displays 5-fold selectivity over SHP1, and >10-fold secltivity over other PTPs.
    SHP2 inhibitor 2 effectively reduces the EGF-induced ERK1/2 phosphorylation, increased the phosphorylation level of Y118 in paxillin, reduces H1975 cell proliferation in a dose-dependent manner.

    物理化学性质&存储条件

    分子量 579.365
    分子式 C22H18IN3O6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4-(2-((4-iodophenyl)amino)-2-oxoacetamido)phenyl)amino)-2-oxo-1-phenylethane-1-sulfonic acid

    参考文献

    1. He R, et al. ACS Med Chem Lett. 2015 Jun 8;6(7):782-6.

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