SHP2 inhibitor 14 |CAS:2055937-44-3 Probechem Biochemicals

Chemical Structure : SHP2 inhibitor 14

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SHP2 inhibitor 14

货号: PC-36051Not For Human Use, Lab Use Only.

SHP2 inhibitor 14 is a novel potent, selective, allosteric, orally acitve SHP2 inhibitor with IC50 of 28 nM.

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1 g		Get quote

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生物&药学活性

SHP2 inhibitor 14 is a novel potent, selective, allosteric, orally acitve SHP2 inhibitor with IC50 of 28 nM; inhibits p-ERK in KYSE-520 cells with IC50 of 93 nM, and shows antiproliferation effect with IC50 of 0.167 uM; demonstrates acceptable stability in mouse liver microsomes (Cl = 36.8, uL/min/mg, T1/2 = 60.2 min) and is sufficiently soluble (pH = 6.8 equilibrium solubility = 0.42 mM) to enable PK pharmacokinetic evaluation; modulate MAPK signaling in vivo in mice subcutaneously implanted with the KYSE520 carcinoma cell line.

物理化学性质&存储条件

分子量	463.363
分子式	C21H24Cl2N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-5-methyl-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

参考文献

1. Bagdanoff JT, et al. J Med Chem. 2019 Feb 8. doi: 10.1021/acs.jmedchem.8b01725.