SHP2-IN-2 |CAS:2162951-06-4 Probechem Biochemicals

Chemical Structure : SHP2-IN-2

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SHP2-IN-2

货号: PC-63257Not For Human Use, Lab Use Only.

SHP2-IN-2 is a selective, allosteric inhibitor of protein tyrosine phosphatase SHP2, preferentially inhibits SHP2 F285S over the PTP domain and allosteric site mutant.

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生物&药学活性

SHP2-IN-2 is a selective, allosteric inhibitor of protein tyrosine phosphatase SHP2, preferentially inhibits SHP2 F285S over the PTP domain and allosteric site mutant。
SHP2-IN-2 reduces the viability of MOLM14 cells with IC50 of 85 uM.

物理化学性质&存储条件

分子量	342.797
分子式	C17H11ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-benzyl-8-chloro-2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one

参考文献

1. LaRochelle JR, et al. Bioorg Med Chem. 2017 Dec 15;25(24):6479-6485.

SHP2-IN-2

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SHP2-IN-2

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