SHP-1 agonist SC-43 | SHP-1 agonist | Probechem Biochemicals

Chemical Structure : SHP-1 agonist SC-43

CAS No.: 1400989-25-4

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SHP-1 agonist SC-43 (SC-43)

货号: PC-20911Not For Human Use, Lab Use Only.

SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1.

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10 mg	￥2280	In stock
25 mg	￥3880	In stock
100 mg		Get quote
1 g		Get quote

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生物&药学活性

SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1.
SHP-1 agonist SC-43 is a sorafenib derivative but displays more potent anti-HCC activity than sorafenib.
SHP-1 agonist SC-43 treatment reduced the activated HSCs and thus effectively prevented and regressed liver fibrosis in both fibrosis mouse models and improved mouse survival.
SC-43 promoted HSC apoptosis, increased the SHP-1 activity and inhibited phospho-STAT3.

物理化学性质&存储条件

分子量	431.80
分子式	C21H13ClF3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea

参考文献

1. Tai WT, et al. Hepatology. 2014 Jan;59(1):190-201.

2. Su TH, et al. Sci Rep. 2017 May 11;7(1):1728.

SHP-1 agonist SC-43 (SC-43)

生物&药学活性

物理化学性质&存储条件

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SHP-1 agonist SC-43 (SC-43)

生物&药学活性

物理化学性质&存储条件

参考文献

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