SHIN2 |CAS:2204289-53-0 Probechem Biochemicals

Chemical Structure : SHIN2

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SHIN2

货号: PC-38150Not For Human Use, Lab Use Only.

SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1.

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生物&药学活性

SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1.
SHIN2 increases survival in NOTCH1-driven mouse primary T-ALL in vivo.
Low dose methotrexate sensitizes Molt4 human T-ALL cells to SHIN2, and cells rendered methotrexate resistant in vitro show enhanced sensitivity to SHIN2.
SHIN2 and methotrexate synergize in mouse primary T-ALL and in a human patient-derived xenograft in vivo, increasing survival.

物理化学性质&存储条件

分子量	406.486
分子式	C23H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-amino-4-(3-(hydroxymethyl)-5-(5-hydroxypent-1-yn-1-yl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

参考文献

1. Juan C García-Cañaveras, et al. Leukemia. 2021 Feb;35(2):377-388.

2. Gregory S Ducker, et al. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.

SHIN2

生物&药学活性

物理化学性质&存储条件

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SHIN2

生物&药学活性

物理化学性质&存储条件

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