SHIN1 |CAS:2146095-85-2 Probechem Biochemicals

Chemical Structure : SHIN1

CAS No.: 2146095-85-2

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SHIN1 (RZ-2994, RZ 2994)

货号: PC-38151Not For Human Use, Lab Use Only.

SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg	￥7280	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM.
SHIN1 blocked growth of HCT-116 cells IC50=870 nM, SHIN1 impairs cell growth at concentrations <100 nM due to its potent engagement of cellular SHMT1.
SHMT inhibition in DLBCL cell lines results in depletion of glycine-derived metabolic products.

物理化学性质&存储条件

分子量	400.482
分子式	C24H24N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (40.1 mg/mL)
Chemical Name/SMILES	6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile

参考文献

1. Juan C García-Cañaveras, et al. Leukemia. 2021 Feb;35(2):377-388.

2. Gregory S Ducker, et al. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.

3. Pikman Y, et al. Leukemia. 2022 Feb;36(2):348-360.

SHIN1 (RZ-2994, RZ 2994)

生物&药学活性

物理化学性质&存储条件

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SHIN1 (RZ-2994, RZ 2994)

生物&药学活性

物理化学性质&存储条件

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