SHA68 | NPSR antagonist | Probechem Biochemicals

Chemical Structure : SHA68

CAS No.: 847553-89-3

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SHA68 (SHA-68)

货号: PC-38622Not For Human Use, Lab Use Only.

SHA68 is a selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50 of 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively, Ke value of 13.7 nM (Ile107 variant).

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生物&药学活性

SHA68 is a selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50 of 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively, Ke value of 13.7 nM (Ile107 variant).
SHA68 induced antidepressant-like effects in bed nucleus of the stria terminalis (BNST) of learned helplessness (LH) rats (an animal model of depression).

物理化学性质&存储条件

分子量	445.494
分子式	C26H24FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide

参考文献

1. Medina G, et al. Mol Pain. 2014 May 29;10:32.

2. Hassler C, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):731-44.

3. Shirayama Y, et al. Behav Brain Res. 2015 Sep 15;291:67-71.

SHA68 (SHA-68)

生物&药学活性

物理化学性质&存储条件

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SHA68 (SHA-68)

生物&药学活性

物理化学性质&存储条件

参考文献

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