SH045 | TRPC6 blocker | Probechem Biochemicals

Chemical Structure : SH045

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SH045 (SH-045, Larixyl-6-N-methylcarbamate)

货号: PC-72566Not For Human Use, Lab Use Only.

SH045 (SH-045, Larixyl-6-N-methylcarbamate) is a potent, selective TRPC6 antagonist (blocker) with IC50 of 63 nM.

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生物&药学活性

SH045 (SH-045, Larixyl-6-N-methylcarbamate) is a potent, selective TRPC6 antagonist (blocker) with IC50 of 63 nM.
SH045 displays 13-fold subtype selectivity over TRPC3 in stably expressing HEK293 cells.
Treatment of isolated perfused lung preparations with SH045 led to a decrease in lung ischemia-reperfusion edema (LIRE), a life-threatening condition associated with TRPC6 that may occur after organ transplantation.

物理化学性质&存储条件

分子量	363.53
分子式	C22H37NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Larixyl-6-N-methylcarbamate

参考文献

1. Stephanie Häfner, et al. ChemMedChem. 2018 May 23;13(10):1028-1035.

2. Zheng Z, et al. Sci Rep. 2022 Feb 22;12(1):3038.

SH045 (SH-045, Larixyl-6-N-methylcarbamate)

生物&药学活性

物理化学性质&存储条件

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SH045 (SH-045, Larixyl-6-N-methylcarbamate)

生物&药学活性

物理化学性质&存储条件

参考文献

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