SH-BC-893 |CAS:1841409-92-4 Probechem Biochemicals

Chemical Structure : SH-BC-893

CAS No.: 1841409-92-4

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SH-BC-893 (PP2A activator SH-BC-893)

货号: PC-35653Not For Human Use, Lab Use Only.

SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve.

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2 mg	￥4580	In stock
5 mg	￥7580	In stock
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25 mg		Get quote

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生物&药学活性

SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve.
SH-BC-893 selectively kills cells expressing an activated form of the anabolic oncogene Ras in vitro and in vivo.

物理化学性质&存储条件

分子量	325.921
分子式	C19H32ClNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((2S,3R)-3-(4-octylphenyl)pyrrolidin-2-yl)methanol hydrochloride

参考文献

1. Kim SM, et al. J Clin Invest. 2016 Nov 1;126(11):4088-4102.

SH-BC-893 (PP2A activator SH-BC-893)

生物&药学活性

物理化学性质&存储条件

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SH-BC-893 (PP2A activator SH-BC-893)

生物&药学活性

物理化学性质&存储条件

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